What is melanoma in situ with regression?

Reappraising “melanoma in situ with regression”

MIS, by definition, is a tumor confined to the epidermis . Yet, a dermatopathology report of “MIS with regression” requires reappraisal to promote accurate tumor characterization.

Is regression good in melanoma?

Subgroup analyses showed that regression was significantly associated with improved recurence-free survival for patients with thin and intermediate Breslow thickness melanomas (≤4.0 mm), and for those with superficial spreading melanoma (SSM) subtype.

What does regression in melanoma mean?

Definition and classification of regression in primary melanoma. Regression of malignant tumors can occur spontaneously or in response to treatment. Spontaneous regression is defined as partial or complete disappearance of a previously documented tumor in the absence of therapeutic interventions or physical trauma .

Can melanoma regress on its own?

In most cases, the tumor outgrows the capability of the immune system to destroy it. In some cases, however, the immune system manages to win, either partially or completely destroying the tumor and resulting in spontaneous regression .

Should I be worried about in situ melanoma?

In situ melanomas don't spread to other parts of the body or cause death, but if the tumor has an opportunity to grow even one millimeter deep into the skin, it can lead to more involved treatment and greater danger . If left untreated, it can metastasize and even become life-threatening.

What does regressed melanoma mean?

Regressive melanoma is a phenomenon characterized by partial or complete replacement of cutaneous melanoma by fibrotic structures as a result of local host immune response

Can melanoma regress on its own?

In most cases, the tumor outgrows the capability of the immune system to destroy it. In some cases, however, the immune system manages to win, either partially or completely destroying the tumor and resulting in spontaneous regression

What is melanoma in situ with regression?

Reappraising “melanoma in situ with regression”

MIS, by definition, is a tumor confined to the epidermis . Yet, a dermatopathology report of “MIS with regression” requires reappraisal to promote accurate tumor characterizatio

What does regression in a mole mean?

When cancer attacks the body, the body's immune system fights back . The immune system may be able to reduce the size of a cancerous mole. In some cases, the mole may disappear altogether. This process is called regression and occurs in 10-20 percent of all melanomas.

Can melanoma spontaneously regress?

From an immune point of view, melanoma, like other solid tumors, may regress spontaneously with partial or complete disappearance of tumor .

What is a regressed melanoma?

Regressive melanoma is a phenomenon characterized by partial or complete replacement of cutaneous melanoma by fibrotic structures as a result of local host immune response .

Can melanoma go dormant?

These studies show that in both uveal and cutaneous disseminated melanoma, cells can remain dormant for longer than a decade , and when they emerge from dormancy they almost invariably are resistant to therapy and fatal.

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